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One-fourth of AAS abusers report major mood syndromes, such as mania, hypomania or major depression, while on AAS (Pope & Katz 1994). Despite many of the studies in this area suffering from methodological inadequacies, they clearly do demonstrate that increased aggression and irritability are associated with AAS abuse (Bahrke et al. Moreover, evidence exists that severity of psychiatric adverse effects is dose-related (Porcelli & Sandler 1998). However, contradictory reports suggest that at least some psychiatric symptoms are associated with life-style and exercise regimen (Bahrke & Yesalis 1994). Because the present study aimed to elucidate selected somatic adverse effects of AAS abuse, psychiatric and behavioural effects were ignored. Effects on cardiovascular system The risk for cardiovascular disease has been found to be increased among AAS abusers (Wilson 1988). Average 24-hour blood pressure levels were not elevated in bodybuilders during AAS administration, but chronic AAS abuse did result in an abnormal 24-hour blood pressure pattern (Palatini et al.

 

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